Epinephrine - Due to the potential for promethazine to reverse epinephrine’s vasopressor effect, epinephrine really should not be made use of to treat hypotension connected with promethazine overdose.
Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Solution Recommend sufferers to effectively eliminate unused Promethazine HCl and Codeine Phosphate Oral Answer. Suggest patients to toss the drug within the house trash next these steps. one) Get rid of them from their primary containers and mix them using an unwanted material, for example applied espresso grounds or kitty litter (this tends to make the drug significantly less appealing to children and pets, and unrecognizable to individuals that may intentionally go with the trash searching for drugs).
Sedation in both of those little ones and adults, and relief of apprehension and production of mild rest from which the individual could be easily aroused.
Warning really should be exercised when promethazine hydrochloride and codeine phosphate syrup is administered to a nursing girl.
Promethazine HCl Oral Resolution administered to some pregnant lady inside two weeks of supply may possibly inhibit platelet aggregation from the new child.
Prescription drug abuse would be the intentional non-therapeutic utilization of a prescription drug, even when, for its here gratifying psychological or physiological outcomes.
For preoperative medication, small children need doses of 0.five mg per pound of entire body fat in combination using an correctly lessened dose of narcotic or barbiturate and the appropriate dose of the atropine-like drug.
Specific scientific studies to check the motion in the drug on parturition, lactation, and advancement on the animal neonate were not performed, but a normal preliminary examine in rats indicated no impact on these parameters.
Acute or severe bronchial asthma within an unmonitored location or in absence of resuscitative gear. (four)
two) Area the combination in a very sealable bag, empty can, or other container to stop the drug from leaking or breaking from a rubbish bag, or to eliminate in accordance with community point out pointers and/or restrictions.
Consideration really should be specified to the discontinuation of promethazine HCl and to the use of other drugs if these reactions manifest. Respiratory melancholy, nightmares, delirium, and agitated conduct have also been reported in A few of these individuals.
Promethazine really should not be Utilized in pediatric clients lower than two decades of age due to likely for lethal respiratory despair.
Simply because opioid agonists may well maximize biliary tract strain, with resultant increase in plasma amylase or lipase ranges, perseverance of such enzyme degrees could possibly be unreliable for twenty-four hrs after administration of the dose of Promethazine HCl and Codeine Phosphate Oral Resolution.
Promethazine is commonly dispersed in overall body tissues. Promethazine has superior protein binding with about 80 to ninety three% of promethazine bound to plasma proteins. Promethazine passes the blood brain barrier as well as placental barrier.